Weight Loss and Gallstones: Why Rapid Dieting Increases Your Risk

Rapid weight loss paradoxically increases gallstone risk. When fat is mobilised quickly, the liver secretes excess cholesterol into bile; simultaneously, reduced caloric intake decreases gallbladder contractions, causing bile stasis. Losing >1.5 kg/week increases risk by up to 30%. Very-low-calorie diets (<800 kcal/day) cause gallstones in 25-35% within 12 weeks. Bariatric surgery (gastric bypass, sleeve gastrectomy) causes gallstones in 30-40% within 6 months without prophylaxis. Prevention after bariatric surgery: UDCA 500-600mg daily for 6 months reduces risk by ~50%; some surgeons perform simultaneous cholecystectomy. Safe weight loss tips: aim for 0.5-1 kg/week, include at least 10g fat per meal (stimulates gallbladder contractions), eat regular meals (3-4/day), stay physically active, consider UDCA if on medically supervised VLCD. Consider ultrasound if you have lost >10% body weight in 3 months.